Endocrine Abstracts

Aim: To investigate the relationship of arterial stiffness with short- and long-term parameters of glycemic control and glycation in patients with type 1 diabetes.Methods: Cross-sectional study at a tertiary care centre including 54 patients with type 1 diabetes free from known CVD. Arterial stiffness was assessed with carotid-femoral pulse wave velocity (cf-PWV). Current level and 10-years history of HbA1c was evaluated, and skin advanced glycation end-...

Objective: Testosterone levels are decreased in male obesity, the mechanism of which is incompletely understood. The aim of this study was to explore determinants affecting the feedback mechanism of the hypothalamic–pituitary–gonadal axis in male obesity and type 2 diabetes (DM2), such as aromatase expression and lipotoxicity.Materials and methods: Circulating levels of testosterone were quantified (<1000 h with LC–MS/MS) in 37 middle-...

Aims: Emerging data indicate that an impaired release of adipose tissue-derived adipokines could play a pivotal role in the development of non-alcoholic fatty liver disease (NAFLD). We aimed to evaluate whether circulating levels or visceral adipose tissue (VAT) expression of recently described adipokines associate with the histopathological disease severity and thus may contribute to the progression of pure fatty liver into an inflammatory and insulin resistant NASH status.</...